General Information

  • ID:  hor004660
  • Uniprot ID:  Q6IWB1(29-96)
  • Protein name:  CLAVATA3/ESR (CLE)-related protein 43
  • Gene name:  CLE43
  • Organism:  Arabidopsis thaliana (Mouse-ear cress)
  • Family:  CLV3/ESR signal peptide family
  • Source:  Plant
  • Expression:  [CLE43p]: Expressed at low levels in seedlings.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0033612 receptor serine/threonine kinase binding
  • GO BP:  GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment
  • GO CC:  GO:0005576 extracellular region; GO:0048046 apoplast

Sequence Information

  • Sequence:  RQVPELSDDQLGKDRNTLMTSKNKNKNEDVQRLFQRYFKGRSFGLNNTNSRFEDSNRRIPSSPDRLHN
  • Length:  68(29-96)
  • Propeptide:  MGCRDILLTFSVALLLISLFQIWLFREGRQVPELSDDQLGKDRNTLMTSKNKNKNEDVQRLFQRYFKGRSFGLNNTNSRFEDSNRRIPSSPDRLHN
  • Signal peptide:  MGCRDILLTFSVALLLISLFQIWLFREG
  • Modification:  T60 Hydroxyproline;T63 Hydroxyproline
  • Glycosylation:  T46 N-linked (GlcNAc...) asparagine;T63 O-linked (Ara...) hydroxyproline
  • Mutagenesis:  NA

Activity

  • Function:  Extracellular signal peptide that regulates cell fate.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q6IWB1-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004660_AF2.pdbhor004660_ESM.pdb

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Physical Information

Mass: 926307 Formula: C341H549N115O111S
Absent amino acids: ACW Common amino acids: NR
pI: 10.94 Basic residues: 15
Polar residues: 23 Hydrophobic residues: 13
Hydrophobicity: -156.47 Boman Index: -29340
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 48.68
Instability Index: 5273.82 Extinction Coefficient cystines: 1490
Absorbance 280nm: 22.24

Literature

  • PubMed ID:  NA
  • Title:  NA